Correction: Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission
نویسندگان
چکیده
Copyright: © 2015 Kovarova et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
منابع مشابه
Nanoformulations of Rilpivirine for Topical Pericoital and Systemic Coitus-Independent Administration Efficiently Prevent HIV Transmission
Vaginal HIV transmission accounts for the majority of new infections worldwide. Currently, multiple efforts to prevent HIV transmission are based on pre-exposure prophylaxis with various antiretroviral drugs. Here, we describe two novel nanoformulations of the reverse transcriptase inhibitor rilpivirine for pericoital and coitus-independent HIV prevention. Topically applied rilpivirine, encapsu...
متن کاملOne percent tenofovir applied topically to humanized BLT mice and used according to the CAPRISA 004 experimental design demonstrates partial protection from vaginal HIV infection, validating the BLT model for evaluation of new microbicide candidates.
Recent iPrEx clinical trial results provided evidence that systemic preexposure prophylaxis (PrEP) with emtricitabine (FTC) and tenofovir disoproxil fumarate (TDF) can partially prevent rectal HIV transmission in humans. Similarly, we have previously demonstrated that systemic administration of the same FTC-TDF combination efficiently prevented rectal transmission in humanized bone marrow/liver...
متن کاملIn search of the optimal delivery method for anti-HIV microbicides: are intravaginal rings the way forward?
© 2013 Expert Reviews Ltd Intravaginal rings are an advantageous microbicide delivery platform Microbicides are urgently needed to help stem the HIV epidemic [1]. With time and resources at a premium, donors, researchers and regulators agree that only the most promising candidates should be pursued (although they do not always agree on how to prioritize them) [2]. Following the realization that...
متن کاملProtection Efficacy of C5A Against Vaginal and Rectal HIV Challenges in Humanized Mice
Introduction In the absence of a vaccine, there is an urgent need for the identification of effective agents that prevent HIV transmission in uninfected individuals. Non-vaccine Biomedical Prevention (nBP) methods, such as topical or systemic pre-exposure prophylaxis (PrEP), are promising strategies to slow down the spread of AIDS. Methods In this study, we investigated the microbicidal effic...
متن کاملLong-acting injectable antiretrovirals for HIV treatment and prevention
PURPOSE OF REVIEW Long-acting antiretroviral (ARV) drugs may improve adherence to therapy and extend opportunities for therapeutic or prophylactic intervention to underserved patient populations. This review focuses on recent advances in the development of small molecule long-acting injectable ARV agents. RECENT FINDINGS The need for combination ART and physicochemical and dosing limitations ...
متن کامل